5-htp

Xiao Bu Xin Tang and BX-2 show antidepressant effect in forced swimming test in mice and rats, as well as in the suspension test and 5-HTP induced head-twitches in mice.

在小鼠强迫游泳试验、小鼠悬尾试验、大鼠强迫游泳试验和小鼠5-HTP甩头试验等多个抗抑郁评价模型上，小补心汤和BX-2均显示抗抑郁作用；

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Finally, the results proved that 5-HTP has some effect on appetite suppression and weight lost.

证明了5-HTP具有一定的抑制食欲、帮助减肥的功效。

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Microinjection of methlysergide ( MS), an antagonist of 5-HT receptor, into the hippocampus, had no direct effect on sleep, but abolished the SWS-promoting effect of 5-HTP completely.

非特异性5-HT受体阻断剂麦角新碱（MS）对睡眠无直接影响，但可完全阻断5-HTP的促睡眠效应。

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The effects of 5-HTP could be abolished by Methysergide ( MS), an antagonist of 5-HT receptor.

5HT受体阻断剂麦角新碱（MS）的效应与5HTP相反，并可阻断5HTP的作用。

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Methods The reserpine reversal test and 5-HTP induced head-twitches test were used in mice.

方法采用小鼠利血平拮抗实验和5-羟色胺酸（5-HTP）诱导的甩头实验。

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BCEF ( 50100 mg · kg~-1) could distinctly increase the head-twitch number in the 5-HTP induced head-twitches test. BCEF50 、 100mg · kg-1

可明显增加5羟色胺酸诱导甩头小鼠的甩头次数

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Potentiation of 5-hydroxytryptophan ( 5-HTP)-induced head twitches: animal grouping was the same as above, and the drug in positive control group was replaced by fluoxetine.

5-羟色胺酸诱导的小鼠甩头实验：小鼠分组同上，阳性对照药换为盐酸氟西汀。

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BCEF ( 50,100 mg · kg~-1) could distinctly increase the head-twitch number in the 5-HTP induced head-twitches test.

BCEF50、100mg·kg-1可明显增加5羟色胺酸诱导甩头小鼠的甩头次数。

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Methods: The antidepressant effect of the several crude extracts of Rhizoma Acori Tatarinowii was evaluated with rat force swimming test, mice tail suspension test and 5-HTP induced head-twitches model in mice.

方法：选用小鼠尾悬挂试验、大鼠强迫游泳试验和小鼠5-HTP诱导的甩头试验模型对石菖蒲的提取物的抗抑郁作用进行研究。

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Simultaneous determination of CSF monoamine metabolites MHPG, HVA, 5-HIAA, 5-HTP and tryptophan by a HPLC method with electrochemical and ultraviolet detectors is introduced.

介绍同时测定脑脊液中单胺类遂质及代谢产物5-HT，5-HTP，Trp，MHPG，HVA和5-HIAA的高效液相色谱法。

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Results ( 1) CTN-986 could increase the head-twitches induced by 5-HTP, which indicated CTN-986 had an antidepressant effect, and the effect was related to the up-regulation of 5-HT transmission system.

结果（1）CTN-986可以增加5-HTP诱导的小鼠甩头次数，进一步提示CTN-986具有明确的抗抑郁活性，并且该活性与增强5-HT神经功能有关；

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Methods The antidepressant effects of Bioactive compounds from entomogenous fungi was examined on the chronic unpredictable stress test, yohimbine induced lethality test, and 5-HTP induced head-twitches test.

方法采用未预知的慢性应激实验、育亨宾毒性实验、5羟色胺酸诱导甩头实验等多种模型研究BCEF抗实验性抑郁作用及可能的作用机制。

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Analgesic Effect of Du Liang Pill ( DLP) Extract and Its Effect on Neurotransmitters 5-HTP, 5-HIAA Contents in Serum

都梁丸提取液镇痛作用及其对血清中5-HTP、5-HIAA含量的影响

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Methods The antidepressant effect of TT was examined by mice forced swimming test ( FST), learned helplessness ( LH) experiment, chronic mild stress ( CMS) model, yohimbine induced lethality test and 5-HTP induced head-twitches test.

方法采用小鼠强迫游泳实验，获得性无助实验，慢性温和应激模型，育亨宾毒性增强实验以及5-羟色胺酸诱导甩头实验等多种动物模型考察TT的抗实验性抑郁作用及其可能的机制。

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The depression model was set up by chronic stimulation and ligate/ perfuse double carotid, and the density of β-adrenergic receptor in hippocampus and 5-HTP receptor in cerebral cortex was determined, and the effect on neurotransmitter of a long-term administration was discused.

通过慢性随机刺激合并结扎/开放双侧颈总动脉制备抑郁模型，并测定其海马组织β-肾上腺素受体和大脑皮层5羟色胺受体密度，研究长期给药对神经递质受体的影响。

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The possible mechanism of its anti-depression effect was studied by 5-HTP or DOI induced head-twitch-response ( HTR) in mice.

采用5-HTP、DOI致小鼠甩头实验探讨逍遥散抗抑郁作用的机制。

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TT ( 50 mg · kg-1, ig, qd × 14 d) enhanced the mortality of mice after administration of yohimbine for 4 h, and distinctly increased the head-twitch number in the 5-HTP induced head-twitches test.

TT（50mg·kg-1，qd×14d）可提高育亨宾给药后4h的小鼠死亡率；并且显著增加5-羟色胺酸诱导小鼠的甩头次数。

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The high and low doses of the effective fraction of Sini Powder ( 600mg/ kg, 300mg/ kg) antagonized the descent of body temperature and ptosis induced by reserpine, and increased significantly the frequency of mouse head flick induced by 5-HTP.

四逆散有效部位大、小剂量（600、300mg/kg）可以拮抗利血平降低小鼠体温、引起小鼠眼睑下垂的作用，明显增加5-HTP诱导小鼠的甩头次数。

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Results BCPT could reverse the blepharoptosis and the akinesia induced by reserpine and increase the number of head-twitches induced by 5-HTP in mice.

结果BCPT可拮抗利血平诱导的小鼠上眼睑下垂及运动不能，并增加5-HTP诱导的小鼠甩头次数。

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